Tibolone is a synthetic steroid hormone prescribed for relieving menopausal symptoms and preventing postmenopausal osteoporosis. Read on to learn in-depth details about it.
- Tibolone Uses
- How Tibolone Works?
- Before Taking Tibolone
- What if I Overdose And Miss A Dose
- Tibolone Side Effects
- Warnings and Interactions
- Buy Tibolone Online
- Consumer Reviews
Tibolone is a type of hormone replacement therapy (HRT) and a man-made female hormone designed to relieve menopausal symptoms and prevent osteoporosis (thinning of the bones) in post-menopausal women. Tibolone HRT is a synthetic hormone also known as the first “bleed-free” HRT which, when taken every day, offers the combined effects of oestrogen, progestogen and testosterone. It is usually used for treating symptoms of oestrogen deficiency, preventing osteoporosis and improving interest in sex. It is available in easy to take tablet form.
Tibolone hormone replacement therapy is used to relieve the symptoms of oestrogen deficiency such as hot flushes, decreased sex drive, depression in women who have gone through the menopause. It is also used for preventing osteoporosis in women who have been through the menopause and are at high risk of fractures, but cannot use other medicines to prevent osteoporosis.
Note that it is only suitable for women who have been through the menopause, and providing there have been at least 12 months since the last natural period. This synthetic steroid hormone is prescribed only when other, more preferred, treatment options are not suitable. Tibolone has also been shown to be mostly useful in women who are known to have endometriosis and fibroids as it does not appear to stimulate these conditions.
How does it Work?
Tibolone works by mimicking the job done by female sex hormones – oestrogen and progesterone. It also has some affect of male hormone – androgen. It helps restoring the balance of female hormones in women who lacks oestrogen and helps to ease symptoms such as hot flushes and night sweats. This medicine will be prescribed only if these symptoms seriously interferes your daily life. It is normally prescribed at least 12 months after the last natural menstrual period. So many women switch to this continuous therapy type only after taking a sequential HRT.
Before Taking Tibolone
Some medicines may not be suitable for people with certain health conditions, and sometimes a medicine may only be used with extra care. For these reasons, before you start taking tibolone it is very important that your doctor is aware about the following
- If any of your close family member had history of breast cancer (eg mother, sister or grandmother)
- You have had a cancer that is hormone-dependent
- If you have any unexplained vaginal bleeding
- You have liver or kidney disease
- If you have high levels of fat (triglycerides or cholesterol) in your blood
- If you have ever had a blood clot in your leg or lungs, or if you have had thrombophlebitis (inflammation of a vein)
- You have angina, or if you have had a heart attack or stroke
- If you ever had an allergic reaction to a medicine
- If you have an ear disorder that may cause hearing loss (otosclerosis)
- You are pregnant
- If you have diabetes mellitus
- You have epilepsy or gallstones
- If you have a rare inherited blood condition, called porphyria.
- If you are taking any other medicines i.e. prescribed, non-prescribed, herbal supplements, etc.
Tibolone dosage is based on your age, medical condition, response to therapy, and use of certain interacting medicines. However the typical dosage is to take this medicine with a glass of water once daily with or without food. Generally you will see an improvement in your symptoms within a few weeks and you should continue to take Tibolone tablets for as long as recommended by your doctor. Usually your doctor will suggest you to take it for the shortest time period required to improve your symptoms, typically at least 3 months but not more than 6 months without doctor’s review. Remember to use it at the same time every day – unless otherwise told by your doctor. Store it in an air tight container. Store it in a below 25°C cool, dry place, away from direct heat and light.
What if you Overdose & Missed A Dose
- Overdose – Symptoms of Tibolone overdose includes feeling sick or being sick and vaginal bleeding. If you think you, or someone you care for, might have accidentally taken more than the necessary dose or intentional overdose is suspected, contact your local hospital immediately or seek medical emergencies, dial 999.
- Missed Dose – If you miss a dosage, take it as soon as you remember only if your next dose is after 12 hours. If you are more than 12 hours late, skip the missed dose and resume your usual dosing schedule. Do not double the dose to avoid overdose.
Tibolone Side Effects
Medicines and their possible side effects may affect individuals in different ways. The following are some of the side effects that are known to be related to the product.
Vaginal bleeding or spotting, Vaginal discharge, Vaginal thrush, Vaginal itching, Breast tenderness, Gut Disturbances such as diarrhea, constipation, nausea, vomiting or abdominal pain, Rash or itching, Seborrhoeic dermatitis, Abnormal hair growth (hypertrichosis), Dizziness, Headache/migraine, Weight gain, Visual disturbances such as blurred vision, Excessive fluid retention in the body tissues, resulting in swelling (oedema), Muscles and Joints Pain, Depression, Alteration in results of liver function tests, Irregular brown patches on the skin, usually of the face (chloasma), Blood clots in the blood vessels (eg, DVT, pulmonary embolism, heart attack, stroke – see warnings above) These listed side effects is not an all inclusive list.
You should stop taking Tibolone and inform your doctor immediately if you experience any of the following symptoms while using Tibolone dose – stabbing pains or swelling in one leg, pain on breathing or coughing, coughing up blood, breathlessness, abrupt chest pain, sudden numbness affecting one side or part of the body, fainting, worsening of epilepsy, migraine or severe headaches, visual disturbances, severe abdominal complaints, increased blood pressure, itching of the whole body, yellowing of the skin or eyes (jaundice) or severe depression.
Commonly seen side effects
However, the most common side-effects of Tibolone are headache, dizziness, nausea, abdominal pain, swollen feet, itching, breast tenderness, weight changes and depression. Initially, irregular slight vaginal bleeding or spotting May also commonly occur but tends to subside after a few months. With Tibolone, Amenorrhea is achieved by nearly 80% of women after the first month of treatment and over 90% after the third month of therapy. As the side effects are mentioned here, does not mean that all people using this medicine will experience that or any side effect.
Warnings & Instructions
Women taking any form of HRT including Tibolone should have regular medical and gynecological check-ups. If you are continuously using HRT, then review with your doctor at least once a year.
- Tibolone And Breast Cancer – It is important to be aware that all women using Tibolone HRT have an increased risk of being diagnosed with breast cancer compared with women who don’t use HRT. Tibolone breast cancer risk should be evaluated against the personal benefits it offers of taking HRT. You should discuss them with your doctor before starting to use this medicine. Women on Tibolone should have regular breast examinations and mammograms and should examine their own breasts regularly. Any changes in your breasts should be reported to your doctor or nurse.
- Bleeding Or Spotting – You may have some bleeding or spotting experienced in the first few months of taking Tibolone. Missing a dose of Tibolone may increase the chance of bleeding. If you are still experiencing any bleeding even after six months of taking this medicine, or if bleeding or spotting starts after six months, or after you have stopped taking this medicine, you should consult your doctor. This is because Tibolone can increase risk of endometrial cancer.
If you are pregnant…
- Pregnancy and Breastfeeding – Tibolone is not for women who are pregnant or breastfeeding. You should stop taking this medicine and consult your doctor immediately if you get pregnant during treatment. Moreover, a woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. HRT such as Tibolone does not provide contraception for women who fall in this group. If you could get pregnant while taking Tibolone, you should use a non-hormonal method of contraception (eg condoms or contraceptive foam). Seek advice from your doctor in this regard.
It is important to tell your doctor what medicines you are already taking, including non- prescription and herbal medicines, before starting treatment with Tibolone. Similarly, before taking any new medicines while using Tibolone check with your doctor to make sure that you are taking safe combination. Here is the list of medicines which may potentially reduce the blood levels and effect of Tibolone, resulting in recurrence of symptoms or irregular bleeding – Antiepileptic medicines such as carbamazepine, phenytoin, phenobarbital and primidone barbiturates such as amobarbital rifamycin and antibiotics such as, rifabutin and rifampicin. Some women with diabetes may require a slight adjustment in their insulin dose or antidiabetic tablets while taking this medicine. You should monitor your blood sugar regularly and seek advice from your doctor if your blood sugar level alters after starting this medicine.
Buy Tibolone Online
It is very easy to buy Tibolone Online. It does not require prescription and is easily available online on some of the top rated online US pharmacy stores such as Quality Prescription Drugs, Mediplus Global Inc., Global Care Rx and many more. Tibolone brands such as tibofem, livial, xyvion, boltin and many more are available here for online sale.
This product is a very useful medicine to help women to relieve post menopausal symptoms. However, this medicine may cause some side effects as mentioned above. So its efficiency entirely depends on how your body reacts to it. Consult your doctor before use. One customer says her hot flushes had vanished but had severe bleeding twice plus had gained a lot of weight upon using this medication. Another customer says she stopped taking it for 6 days and the severe headaches returned. So she again started taking Tibolone even though it caused her side effects such as joint pain and excessive body hair growth.
One more user says she is using Tibolone for 2 months now and had helped her with some menopausal symptoms, like bladder pain, dryness but she feels extremely tired and her joints are very painful. The negative effects, however, override its benefits and ultimately she stopped using it to find herself pain free.
To summarize, Tibolone Customer Reviews, I would say that the product works very well and does its intended job successfully. But these benefits are accompanied with some risk and side effects. So evaluate your personal Tibolone risk v/s benefits, consult your doctor and only then use this product.
Tibolone is a non prescription medicine that can be easily bought online. There are many companies offering this medicine under separate brands. So, go through their individual reviews and select the best for you in consultation with your doctor.