There are more than 300 different amino acids that are present in nature and it is only 20 main amino acids that serve as a building block of proteins and L-Lysine is an important one among them. Lysine is one of the building blocks of protein which is an amino acid that is commonly present in cheese, beans, meat, milk, wheat germ and other animal proteins. But lysine content is low in such grains as wheat and corn.
In the absence of moisture. Lysine was first isolated from milk phosphoprotein – casein in the year 1889. It was first introduced in United States as Lysine Hydrochloride in the year 1955. There was an interest in fortifying bread with lysine. The FDA was against modifying the standards of identity for white bread; however, from 1970 lysine has been commonly added to animal feed. As the human body cannot manufacture lysine naturally, we should supply it to the body in essential amounts to play its functions in the body. Lysine which is also popular as L-lysine is one of the eight essential amino acids.
To supply the body with lysine one has to have food that are rich in lysine through their dietary supplements. L-lysine is necessary for the development and also for growth of the person. L-lysine in the body helps to synthesize Carnitine which is necessary for the conversion of fatty acids to energy form. It also aids in absorption of calcium and also in the formation of the collagen which is very important for bone and muscle health.
SCIENTIFIC NAMES OF LYSINE: Alpha-epsilon-diaminocaproic acid , 2,6-diaminohexanoic acid
Available Forms Of Lysine
Most of the amino acids that are present are in stereoisomers , two forms are– D and L form which are mirror images. Among the D and the L form, it is only L form of amino acid that becomes active to the protein. Thus it is very useful in processing the functions of the body. Few of the amino acids like lysine will benefit health when taken naturally and also as a dietary supplement.
Metabolism Of Pure Encapsulations Lysine
The metabolism of lysine in the humans gives Acetyl CoA through initial transamination that occurs along with alpha ketoglutarte. Allysine is a derivative of lysine which is important for the production of collagen and elastin. The body produces it by the actions and reactions on lysine by the enzyme lysyl oxidase in the extracellular matrix. It is also essential in the cross link formation that stabilizes elastin and collagen.
Requirement Of L-Lysine In Body
The average 70kg human body requires 800 to 3,000mg of lysine on daily basis. We should supply it to the human body through diet as our body cannot produce it.
Lysine studies shows that it is good for the prevention and also treatment of herpes infections and cold sores. It is useful in treating and preventing cold sores which is due to a virus named as herpes simplex labialis. It is also useful in improving the athletic performance. Another main useful feature is that it prevents the growth of herpes virus. Many studies suggest that lysine when taken by mouth and also when we apply it as a cream to the skin has effects on muscle mass increase, improving anxiety and lowering glucose. Few studies suggest that it may ameliorate angina. It has been very useful in treating pain and to detoxify the body from harmful effects after heroin use. Lysine Clonixinate is also useful in treating migraine headaches and also for certain painful conditions. But there are only a few clinical trials that prevail in these conditions.
The Role Of L-Lysine In Healing Herpes Simplex Virus (Hsv)
Few studies show that lysine when taken regularly will help in preventing outbreaks of cold sores and genital herpes. Few other studies show no improvement. Lysine also has antiviral effects by blocking arginine activity which promotes HSV replication. Few studies on the other side reports that oral lysine is more effective for preventing the outbreak of HSV than reducing the duration of an outbreak and severity. Few reports that having lysine at the beginning of the outbreak of herpes did not help in reducing the symptoms. Most experts who have done a good study in this topic believes that lysine do not improve the healing of cold sores.
The Role Of L-Lysine In Treating Osteoporosis
Lysine helps the body to absorb calcium, by reducing the amount of calcium which goes in urine. Calcium is a must for bone health; some researchers think lysine aids to prevent bone loss due to osteoporosis. Lysine with L-arginine helps in making the bone building cells more active and also aids in increasing the production of collagen. But no studies or researchers have examined or confirmed if lysine helps in treating or preventing osteoporosis in humans.
L-Lysine For Athletic Performance
Lysine is one of the common components in athletes protein supplement. Few studies suggests that it helps in muscle tissue recovery after stress.
Dietary Sources Of L-Lysine
Lysine is rich in protein rich foods such as cheese, Meat, Fish, Eggs, Soybeans, Spirulina and fenugreek seed. And also rich in certain foods like brewer’s yeast, legumes, beans and other dairy products.
Lysine is a limiting amino acid which is present in most cereal grains but is also present in more quantities in most pulses. Meals which combine legumes and cereal grains such as rice and Indian dhal or falafel with pita bread provide complete proteins in the diet that is required for the body in the day.
If you want to know if the food that you had has good amount of lysine, you just have to know that it has to be at least 51% lysine per gram of the protein.
Lysine is available in many forms- creams, liquid, capsules and is also sold in L-Lysine form.
Modifications Of L-Lysine
If we require modifications of L-lysine, then it can be possible through acetylation, ubiquitination, methylation, sumoylation, neddylation, biotinylation, carboxylation and pupylation.
L-Lysine And L-Arginine In Reducing Anxiety
Low levels of lysine deficiency can lead to overall deficiency of the proteins and will lead to unhealthy immune system. It also lead to growth failure and also will elevate the levels of stress and anxiety. Studies signify that dietary supplement of L-lysine has been shown to reduce anxiety in healthy humans with low dietary intake of L-lysine. A combination of L-lysine with L-arginine has been shown to normalize the levels of stress response in human with high levels of anxiety. A study on Japanese adults confirms that without any discrimination to the gender, a combination of L-lysine with L-arginine reduce both anxiety trait and state anxiety. This combination also reduce the levels of salivary cortisol and chromogranin –A which is a salivary maker of the sympatho adrenal system.
Benefits Of Having L-Lysine
L-Lysine is an indispensable component in the body; it plays an important role in the collagen and carnitine production. The main benefits of L-lysine in the body are:-
- It helps in the normal growth and development by increasing the formation of collagen.
- It also aids in converting the fatty acids to energy forms, also aids in reduction of weight.
- L-lysine helps in promoting bone health by increasing the absorption of calcium; it prevents osteoporosis and also prevents the occurrence of weak bones by reducing the bone loss.
- It helps in lowering the bad cholesterol levels, thus aids indirectly in reducing the risk for occurrence of heart disease.
- When lysine is taken along with vitamin C, it is reported to reduce the chest pains that are related to heart diseases.
- It has a great role in supporting various numbers of antibodies, hormones and enzymes.
- L-lysine also aids in promoting the health of the skin by increasing the collagen formation.
- Few studies show that it is useful in treating viral infections like, cold sores, herpes simplex, human papilloma virus, genital warts and genital herpes.
- It can also relieve migraines and also helps in getting relieve from few types of inflammation and pain.
Precautions & Warnings While Using L-Lysine
- There are no enough information that it is safe to take Lysine if you are breastfeeding or pregnant. So to stay on the safe side, avoid the use of Lysine.
- Few studies report that kidney disease is linked with taking lysine supplements. If you are already know of a kidney disease, meet a doctor before having it.
- Lysine when had along with calcium supplements reports of increase in calcium absorption.
- Lysine supplementation might cause stomach cramps and diarrhea in children who are intolerant to lysinuric protein.
- L-lysine also helps in building of the muscle when it is taken with arginine which is an amino acid.
Few Clinical Significance Of L-Lysine
When researches were done based on the clinical significance of L-lysine, it was found that it is beneficial for people who are suffering from Herpes simplex infections. Lysine also has anxiolytic action through its actions on serotonin receptors in the intestinal tract, and also reports that it reduces the anxiety through serotonin regulation in the amygdale. Lysine also acts as a serotonin antagonist and therefore helps in lowering the over activity of these receptors. It also helps in reducing the signs of anxiety and diarrhea that comes due to anxiety.
Few clinical researchers also shows that when there is a lysine deficiency, it can lead to increase in the levels of serotonin in the brain that can cause emotional regulation and also stress response.
Few lysine conjugates show that it has positive effects in the treatment of cancer. When the drug combines with the use of photo-therapy, it destroys the cancerous cells. And it also leaves the non cancerous less unaffected or unharmed.
Very limited studies shows that diet high in lysine or Lysine monochloride supplements may have effect in the blood pressure and also affects the incidence of stroke.
Certain Warning While You Place Order Of L-Lysine Online
- Make sure you order L-lysine supplements of a reputed manufacturing company.
- Only consume the recommended dose.
- Order only the required amount of it.
- When L-lysine is delivered, make sure that the tamper seal is not broken. If it’s broken, ask for replacement.
- Check for the expiry date of the supplements provided. If it’s nearing expiry dates on delivery, ask for replacement.
- Check if you are allergic with the ingredients that are present in the supplement. If you are, do not have the supplement without medical concern.
Missing A Dose Of L-Lysine Supplement
If you are having a supplement, take care not to miss the supply. A supplement will be effective only when you consume it in the right time in the right dose. If in any case you miss a dose of L-lysine supplement, do not panic. Relax and have the next regular dose if it’s time for it. Never ever have the missed dose and regular dose of L-Lysine supplement together.
Overdose Of L-Lysine Supplements
Overdose of any supplement is not safe, and so too L-lysine. In case of any accidental consumption by children or by pets – do not wait for any abnormal reactions or symptoms to occur. Seek a medical emergency as soon as possible.
Expiry Date Of L-Lysine Supplements
In case, if your L-lysine supplements has crossed the expiry date do not have them as the reactions beyond this date is not guaranteed. Having them can lead to many other reactions that can be harmful to you.
Disposal Of L-Lysine Supplements
It is not only important in having the medicine in the right time, the disposal of L-lysine supplements is equally important to follow a healthy track from the very beginning- the prevention. We should dispose it in the safest method. Trashing them in dustbins or flushing them in toilets can lead to serious pollution problems. That can affect you indirectly.
How long should we use L-LYSINE?
The longetivity of use of L-lysine will depend on the medical condition for which you are having l-lysine. You doctor will prescribe the required amount for the required duration. Make sure that you meet the doctor before and after having the L-lysine supplements.
Is it safe to have L-LYSINE if I am taking other medication(s)?
No, it isn’t safe to use L-Lysine with other medications. Meeting a doctor with the list of medications that you have had or are having will help the doctor to rule out whether interactions are safe or not in your body.
Are the ingredients of L-LYSINE present naturally in our body?
No, L-lysine is not present in the body naturally. But it is one of the main amino acid that is essential for our body.
Is it safe for everybody to have L-LYSINE?
No, it isn’t safe for everybody to have L-lysine. Consult, a doctor to know if it is safe in your body.
Can children take L-LYSINE?
Check with your pediatrician if L-lysine is necessary for your children. If they rule out a deficiency of L-lysine then they will prescribe L-lysine.
Will I have an addiction to L-LYSINE if I use it for a longer period of time?
Most of the manufacturers that supply L-lysine do not add addictive ingredients along with L-lysine. Make sure that you get a good rated company’s supplement.
What should I do if I think I have been injured as a result of using L-LYSINE?
In case of you feel you are affected with only side effects of L-lysine, stop consuming the supplement of L-lysine and seek a medical emergency as soon as possible.
Can l-lysine used for any non medical uses?
No, L-lysine is not promoted for non medical use.
Interaction Of L- Lysine
Lysine has the ability to increase the calcium absorption. Calcium when taken along with lysine can increase the amount of calcium in the body. Avoid taking large amount of calcium when you are planning to take lysine at the same time.
Arginine and Lysine are building blocks that share common pathways in the body. Few studies have shown that high levels of arginine will lower the lysine levels in the body.
Antibiotics like neomycin, gentamycin and streptomycin when used with lysine may increase the risk of Nephrotoxicity.
Dosage Of Having L-Lysine
If you are having lysine for cold sores – herpes simplex labialis: have 1000mg daily for 1 year and 1000mg three times daily for half year.
For applying in the skin for treating cold sores- a combination of lysine and zinc oxide with 14 other medical ingredients is applied every 2 hours for continuous 11 days.
Toxicities Of L-Lysine
Higher doses of lysine are reported to be safe. When doses of 100mg/kg were given to 2 patients with Parkinson’s disease, no adverse effects was reported.
Deficiency Of L-Lysine
There are chances for occurrence of deficiency in lysine, if one isn’t having a diet that is deficient of lysine. The main health problems that are found to be linked with the deficiency of L-Lysine are low production of thyroid hormone, formation of kidney stone, asthma, abnormal development and growth, chronic viral infections etc.
The Symptoms That Signifies That You Are Deficient Of L-Lysine
Few symptoms that show that you are deficient of L-Lysine are nausea, anemia, dizziness, fatigue and loss of appetite. Recent studies have reported that the deficiency of lysine had been linked with few disorders of reproductive system.
How To Deal With The Deficiency Of L-Lysine
To have normal levels of lysine in the body, you just have to follow the steps in your daily routines and diet:-
Avoid high sugar: to prevent the deficiency of L-lysine, one should be ready to avoid sugar, since sugar binds with lysine.
If you are having high doses of arginine, it can be due to high intake of arginine which is an amino acid. So, avoid the intake of arginine to compensate the levels of lysine in the body.
Consume more proteins: Intake more of proteins through red meat, eggs, and dairy products will help in restoring lysine in the body. Few fish like cod and sardines, nuts, soybean flour, fenugreek, brewer’s yeast are reported to be good sources of lysine.
If in case you are in need of a supplement to increase the L-lysine , lysine supplements are available in the form of liquids, capsules and tablets.
How To Buy L-Lysine Supplements
If you are prescribed with or if you feel you are in need of such a supplement, you can purchase it from online stores or from a health store without prescription, but make sure that you meet a doctor before having this supplement or beware of the interactions, dose, positive side effects and negative effects of L-lysine.
Why Is It So Important To Meet A Doctor Before Having L-Lysine
It is very important to consult a doctor before having any supplement, if you wish to be on the safer side of health. Every supplement may not have the same result for everybody, and moreover, the safe dose should be determined by checking your body’s weight, age and the present and the past medical condition. When you are planning to have a prior appointment with doctor, the doctor will evaluate if there is a requirement of L-lysine in the body. After confirming he will evaluate the present medical condition and the past medical records and the medications that you are taking presently. If L-lysine has less interaction with those medications, you are safe in having L-lysine. It is after checking with all these criteria’s that a doctor prescribes a medication in you.
Side Effects Of L-Lysine
Any dietary supplement to the nutrition routine is safer when done under the supervision of a qualified health care provider. Higher doses of lysine can lead to the formation of gallstone or might develop the kidney disorders. L-lysine can also react with antibiotics so as to produce toxicity. Lysine is possibly safe for when taken orally or when applied to skin for a short term. The most common side effects that are caused are diarrhea and stomach pain.
Natural methods should be the first given preference before directly attempting the dietary supplement.